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ENNew product | New non-invasive screening, helping you maintain a healthy "intestines" for a long time
2023-03-10
Colorectal cancer (CRC) is one of the most common malignant gastrointestinal tumors seriously endangering human health, with a high incidence rate and mortality rate worldwide. According to the latest global cancer burden data in 2020 released by the International Agency for Research on Cancer (IARC) of the World Health Organization, 560000 new cases of colorectal cancer occurred in China in 2020, accounting for 12.2% of all new tumor cases; The number of deaths is 290000, accounting for 9.5% of all cancer deaths.
▲Ranked second in the number of cases of colorectal cancer
With the improvement of people's living standard and the change of lifestyle, especially the change of diet, the incidence rate of colorectal cancer is increasing day by day, which seriously endangers the health of Chinese residents.
The earlier the intervention for colon cancer, the greater the benefits
Generally speaking, the development of colorectal cancer takes 10-15 years, and we can achieve sufficient time to detect and cure it through early screening before it becomes cancerous.
However, 60-70% of patients are diagnosed with mid to late stage colon cancer, while only about 10% of patients are diagnosed with early stage. According to statistics from the United States Preventive Services Task Force (USPSTF), if healthy individuals undergo regular screening every year, they can avoid about 60% of CRC deaths, and the average 5-year survival rate can increase from 46% to 73%. Therefore, an effective early screening method for colorectal cancer can improve the 5-year survival rate and thus reduce mortality.
▲Early intervention for colorectal cancer has a high survival rate
The prognosis and diagnostic staging of colorectal cancer are closely related, and screening, early diagnosis and treatment are of great significance for improving patient survival rate. With the advancement of technology, in addition to traditional colorectal cancer screening methods such as fecal occult blood, digital rectal examination, and colonoscopy, there is also a new detection method - human colon cancer gene methylation detection, which is a non-invasive colorectal cancer screening technology.
02 Advantages of methylation detection technology
- precise：No blind spots detected, specificity reached 95.9%, early sensitivity reached 76.6%;
- Early diagnosis：Early detection of precancerous lesions and early colorectal cancer;
- no-invasive：No need for intestinal preparation, only blood drawing is required.
Therefore, gene methylation detection can serve as a marker for early tumor screening and a prognostic indicator, with great potential in clinical colorectal cancer screening.
03 Borui Biomethylation Detection to Assist Early Screening of Colorectal Cancer
Shenzhen Borui Biotechnology provides solutions and products around integrated digital PCR equipment, reagents, and supporting consumables, actively promoting early screening of colorectal cancer.
Borui Biological Integrated Digital PCR Instrument DropXpert S6
The Borui Biological Digital PCR instrument has a simple operation process, accurate and efficient results, and improves the ability to detect early. Applying digital PCR to gene methylation detection can greatly improve the sensitivity and specificity of detection and achieve absolute quantification.
Borui Biological DropXpert S6 Operation Process
04 血液基因甲基化检测，让肠癌早筛更精准
The Borui Biohuman Spetin9, SDC2, SFRP2 methylation detection kit is a rapid detection kit based on integrated digital PCR. This kit is used for early screening of colorectal cancer by detecting methylation at three gene loci, combined with the accuracy of digital PCR quantification.
Borui Biohuman Spetin9, SDC2, SFRP2 Methylation Detection Kit
Early screening of colorectal cancer is crucial for improving patient survival. Digital PCR technology has the advantages of accurate quantification, high sensitivity, and good reproducibility in detecting gene methylation. Borui Biotech has developed a methylation kit for the human Septin9/SDC2/SFRP2 site, which combines its own technical advantages. The preliminary verification results are good, and it can provide a new solution for early screening of colorectal cancer tumors.
05 Pay attention to the prevention of colorectal cancer
The Chinese Consensus on Colorectal Cancer Prevention states that 66% -78% of CRC can be avoided through the following measures:
● Adjusting dietary habits
● Change lifestyle habits
● Regular screening and active treatment of precancerous lesions
As a leading enterprise in the field of digital PCR, Borui Biotech's journey goes beyond the goal of colon cancer. It always adheres to the concept of "using the power of technology to see the quality of life", and tirelessly explores more early screening fields for cancer. It is committed to the research and development of innovative technologies for tumor screening, helping to detect, diagnose, and treat cancer early.
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